Applications
Layout
Web applications should use the centre column layout (as per this example) unless more space is required (for example: an application that requires large maps).
Standalone applications
If the applicaton stands alone independent of a website the site navigation bar may be removed (as per this example). In this case, the left column may be used for a short summary or overview of the application.
Asides
The asides column can be used for supplementary or related information. For applications with "shopping" functionality, it is common for "shopping cart" to appear as the first aside in the asides column.